| 摘要 |
The current invention concerns an automated method for the production of formulations comprising antibodies against Respiratory Syncytial Virus (RSV) comprising the steps of culturing cells in at least one high cell density bioreactor, thereby fluidly connecting said bioreactor with a culture medium supply and a gas or gaseous mixture; fluidly connecting said bioreactor with a downstream unit; and growing cells to a density at least 50 million cells per ml. The bioreactor total volume is at least 10 liters. The invention also provides a system suitable for implementation of the method. The system is a small-scale cupboard-sized system and can be placed in a portable clean room. |
