TETRABRANCHED PEPTIDES AND ANALOGUES AS A NEW CLASS OF ANTIMICROBIALS AND THEIR PREPARATION THEREOF

摘要

An isolated peptide tetramer includes the formula [(RGRKVVRR)2K]2KK and its derivatives thereof. The derivatives may include at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.

主权项

1. An isolated peptide tetramer comprising the formula [RGRKVVRR)2K]2KKi or an isolated peptide tetramer derivative of peptide tetramer [(RGRKVVRR)2K]2KKi with an initial peptide monomer (RGRKVVRR); comprising at least one amino acid substitution, at least one amino acid deletion, a rearrangement of at least one peptide monomer compared to the initial peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer compared to the initial peptide monomer; wherein i=0 or 1.