| 主权项 |
1. A process for preparing tiotropium salts of formula 1wherein X− represents bromide,comprising:
reacting in one step a compound of formula 2wherein Y− is hexafluorophosphate,
with a compound of formula 3wherein R is methoxy or ethoxy,
in a solvent selected from acetone, acetonitrile or pyridine with the addition of a catalyst selected from zeolites to obtain a compound of formula 4wherein the group Y− has the meaning given above, and
without being isolated, the compound of formula 4 is converted into the compound of formula 1 by reacting formula 4 with a salt cat+X−, wherein cat+denotes a cation selected from the group consisting of Li+, Na+, and K+, and X− has the meaning given above. |
