| 摘要 |
<p>Process for the manufacture of a compound of the structure
with
R 1 = hydrogen, alkyl (C1 - C10, linear, cyclic or branched, aliphatic or aromatic), NR'R'' (wherein R' and R'' are independently selected from H, alkyl [C1 - C10, linear, cyclic or branched, aliphatic or aromatic] and
R 2 = CH 2 R 3 wherein R 3 is selected from NHR''' (with R'' = C(O)H, C(O)CH 3 , C(O)alkyl, CH 2 C 6 H 2 (OMe) 3 or other saponifiable residues), alkyl (C1 - C10, linear, cyclic or branched) aromatic residues, heteroaryl residues, substituted aryl residues, e.g. 3,4,5-trimethoxy-phenyl).
wherein 1 equivalent of an ±-formyl-propionitrile salt is reacted with 0.75 to 2 equivalents of an acetamidine salt in the presence of a Lewis acid.</p> |
