DUAL ANTI-PLATELET MEDICATION/ASPIRIN RESPONSE AND REACTIVITY TEST USING SYNTHETIC COLLAGEN

摘要

The present invention provides tests that measures functional platelet aggregation such as by using Light Transmission Aggregometry Assays (LTAAs) or flow cytometry, using synthetic, self-assembling human type I collagen, methods of predicting and measuring an individual's platelet anti-platelet medication sensitivity and residual platelet activity status when the individual is on a dual anti-platelet therapy of aspirin and anti-platelet medication and kits useful in the assays and methods.

主权项

1. A platelet aggregation assay comprising a light transmission aggregometry assay for determining an individual's residual platelet reactivity status, when the individual is on a dual therapy of aspirin and an anti-platelet medication that is not aspirin, the assay comprising the use of synthetic collagen at a final concentration in the light transmission aggregation assay from about 12.5 ng/mL to about 39 ng/mL.