OSMOTIC DEVICE CONTAINING AMANTADINE AND AN OSMOTIC SALT
摘要
<p>The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is modified from a first order release profile to a zero order, pseudo-zero order or sigmoidal release profile by increasing the amount of the osmotic salt in the core of the device. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt.</p>
申请公布号
EP1834638(B1)
申请公布日期
2015.08.12
申请号
EP20050857295
申请日期
2005.12.02
申请人
OSMOTICA KERESKEDELMI ÉS SZOLGÁLTATÓ KFT
发明人
MEYER, GLENN A.;FELEDER, ETHEL C.;RICCI, MARCELO A.;COPPARI, MARCELO A.;BEFUMO, MARCELO E.;FAOUR, JOAQUINA;VERGEZ, JUAN A.