发明名称 |
Method for purifying teriparatide (PTH1-34) |
摘要 |
The present invention relates to a novel method for purifying teriparatide, a therapeutically active polypeptide fragment of full-length human parathyroid hormone. The method is based on ion exchange chromatography and is effective in separating the therapeutically active polypeptide from undesirable variants, such as truncated polypeptides. The method of the invention can be used at a preparative scale which allows it to be implemented into the production process for teriparatide. Accordingly, the invention also provides a method for the production of teriparatide which includes a step in which teriparatide is purified by the novel ion exchange chromatography method of the invention. |
申请公布号 |
EP2905289(A1) |
申请公布日期 |
2015.08.12 |
申请号 |
EP20140154713 |
申请日期 |
2014.02.11 |
申请人 |
RICHTER-HELM BIO TEC GMBH & CO. KG |
发明人 |
REICH, CHRISTOPH;KUECHLER, MICHAEL |
分类号 |
C07K14/635;C07K1/18 |
主分类号 |
C07K14/635 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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