发明名称 |
THERAPIES BASED ON CONTROL OF REGULATORY T CELL STABILITY AND FUNCTION VIA A NEUROPILIN-1:SEMAPHORIN AXIS |
摘要 |
The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis. The present invention satisfies this and other needs by demonstrating that the regulatory T cell (Treg)-restricted neuropilin-1 (Nrp 1) interacts with the cell surface ligand semaphorin-4a (Sema4a) (e.g., on conventional T cells (Tconv), conventional dendritic cells (cDCs), and/or plasmacytoid dendritic cells (pDCs)) to potentiate reg function and enhance their survival at inflammatory sites. |
申请公布号 |
EP2903692(A2) |
申请公布日期 |
2015.08.12 |
申请号 |
EP20130846146 |
申请日期 |
2013.10.08 |
申请人 |
ST. JUDES CHILDREN'S RESEARCH HOSPITAL |
发明人 |
VIGNALI, DARIO, A. A.;WOO, SENG-RYONG;DELGOFFE, GREG, M. |
分类号 |
A61P37/02;C07K14/00;C12N5/0783 |
主分类号 |
A61P37/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|