METHODS OF QUANTITATING HEAVY AND LIGHT CHAIN POLYPEPTIDE PAIRS
摘要
Provided is a method of quantitatively determining the ability of individual IgG heavy chains to selectively pair with a particular IgG light chain when the heavy chains and two unique light chains are co-expressed. The method provides results with reasonable throughput and is robust and accurate. The co-expressed heavy and light chains do not need to be isolated and purified which enables more efficient screening.
申请公布号
EP2904093(A1)
申请公布日期
2015.08.12
申请号
EP20130843363
申请日期
2013.10.03
申请人
ZYMEWORKS, INC.;NATIONAL RESEARCH COUNCIL OF CANADA (NRC);BAARDSNES, JASON;O'CONNOR-MCCOURT, MAUREEN