发明名称 |
COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY |
摘要 |
<p>Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.</p> |
申请公布号 |
EP1896391(B1) |
申请公布日期 |
2015.08.12 |
申请号 |
EP20060773214 |
申请日期 |
2006.06.14 |
申请人 |
BAYLOR UNIVERSITY |
发明人 |
PINNEY, KEVIN, G.;SRIRAM, MADHAVI |
分类号 |
C07C43/215;A61K31/12;A61P35/00;C07C43/23;C07C49/82 |
主分类号 |
C07C43/215 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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