发明名称 METHOD FOR IMAGING CELL USING FLUORESCENCE-LABELED SUGAR DERIVATIVE HAVING COUMARIN DERIVATIVE BOUND THERETO, AND IMAGING AGENT
摘要 The present invention aims at providing: a sugar derivative capable of producing a blue fluorescent col-or, which can be used for the imaging of a cell or an intracellular molecule; and a method for imaging a cell using the derivative. The present invention also aims at providing: a method for detecting a cancer cell with high accuracy by means of imaging; and an imaging agent for use in the method. The present invention provides: a fluorescence-labeled sugar derivative having, in the molecule thereof, 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-di-fluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group; and an imaging agent for a cell and a method for imaging a cell, in each of which the derivative is used. The present invention also provides an imaging agent for a cancer cell and a method for imaging a cancer cell, in each of which an L-glucose derivative having, in the molecule thereof, the fluorescent molecular group is used.
申请公布号 EP2905620(A1) 申请公布日期 2015.08.12
申请号 EP20130843405 申请日期 2013.10.01
申请人 HIROSAKI UNIVERSITY 发明人 YAMADA, KATSUYA;TESHIMA, TADASHI;YAMAMOTO, TOSHIHIRO
分类号 G01N33/58;A61K49/00;C07H5/06;C07H15/12;C12Q1/02 主分类号 G01N33/58
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