| 发明名称 |
Virus filtration of liquid factor VII compositions |
| 摘要 |
The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide). |
| 申请公布号 |
US9102762(B2) |
申请公布日期 |
2015.08.11 |
| 申请号 |
US201213349980 |
申请日期 |
2012.01.13 |
| 申请人 |
Novo Nordisk Healthcare AG |
发明人 |
Christensen Jesper;Halkjær Erik;Preuss Turid;Hansen Thomas Budde;Tomoda Lene Vædele Madsen;Johansen Nina |
| 分类号 |
C07K14/745;C12N7/00;C12N9/64 |
主分类号 |
C07K14/745 |
| 代理机构 |
|
代理人 |
Akopyan Nonna G. |
| 主权项 |
1. A method for removing viruses from a liquid composition of recombinant Factor VII comprising one or more Factor VII polypeptides having a concentration in the range of 0.01 to 5 mg/mL, the method comprising subjecting the liquid composition to nanofiltration using a nanofilter having a pore size of 80 nm or less, wherein 50-100% of the Factor VII polypeptides in the composition subjected to the nanofilter are in an activated form (FVIIa) prior to nanofiltration. |
| 地址 |
Zurich CH |
