| 发明名称 |
Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors |
| 摘要 |
There is provided a compound of formula I:;
or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer. |
| 申请公布号 |
US9102670(B2) |
申请公布日期 |
2015.08.11 |
| 申请号 |
US201313859270 |
申请日期 |
2013.04.09 |
| 申请人 |
KUDOS PHARMACEUTICALS LIMITED |
发明人 |
Duggan Heather Mary Ellen;Leroux Frederic Georges Marie;Malagu Karine Fabienne;Martin Niall Morrison Barr;Menear Keith;Smith Graeme Cameron Murray |
| 分类号 |
A61K31/5377;C07D413/14;C07D471/04;C07D475/08;C07D475/10 |
主分类号 |
A61K31/5377 |
| 代理机构 |
|
代理人 |
Gillespie Julie Anne |
| 主权项 |
1. A method of treating cancer ameliorated by the inhibition of mTOR in a warm-blooded animal having the cancer, which comprises administering to said animal an effective amount of a compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:
X8 is N, X5 and X6 are CH; R7 isand
R2 is |
| 地址 |
London GB |
