Recombinant Gallid herpesvirus 3 (MDV serotype 2) vectors expressing antigens of avian pathogens and uses thereof

摘要

The present invention provides recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain and express antigens of avian pathogens, recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain a mutated gC gene, compositions comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors, polyvalent vaccines comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant Gallid herpesvirus 3 (MDV-2) vectors.

主权项

1. A vaccine composition comprising:
1) a recombinant Gallid herpesvirus 3 (MDV-2) strain SB-1 vector, wherein said vector comprises a heterologous polynucleotide coding for and expressing in vivo, a Newcastle Disease Virus (NDV) Fusion protein (NDV-F), and 2) a pharmaceutically or veterinarily acceptable carrier, excipient, vehicle or adjuvant; wherein the NDV-F protein has at least 99% sequence identity to a polypeptide having the sequence as set forth in SEQ ID NO:2 or wherein the NDV-F protein comprises SEQ ID NO:9.