Compositions with modulating agents

摘要

The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.

主权项

1. A waterless composition comprising one or more active agents and a carrier, said carrier comprising
a) a modulating agent; b) a polyol; c) a surface active agent; and d) a foam adjuvant; wherein the one or more active agents are chemically unstable in the carrier in the absence of a modulating agent; wherein the modulating agent is capable of and is selected to modulate or adjust the artificial pH of the carrier to an artificial pH or to provide an artificial pH buffering effect such that the chemical stability of the at least one active agent is increased as compared to its stability in the carrier without the modulating agent wherein if the waterless composition is packaged in a pressurized container and propellant is added the composition will be capable upon release of expanding to form a breakable foam.