发明名称 |
Use of non-toxic crosslinking reagents to improve fatigue resistance and reduce mechanical degradation of intervertebral disc and other collagenous tissues |
摘要 |
A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. The crosslinking reagent includes a crosslinking agent such as genipin and/or proanthrocyanidin. Further, the crosslinking reagent may include a crosslinking agent in a carrier medium. The collagenous tissue to be contacted with the crosslinking reagent is preferably a portion of an intervertebral disc or articular cartilage. The contact between the tissue and the crosslinking reagent is effected by injections directly into the select tissue using a needle. Alternatively, contact between the tissue and the crosslinking reagent is effected by placement of a time-release delivery system such as a gel or ointment, or a treated membrane or patch directly into or onto the target tissue. Contact may also be effected by, for instance, soaking. |
申请公布号 |
US9101602(B2) |
申请公布日期 |
2015.08.11 |
申请号 |
US201012966812 |
申请日期 |
2010.12.13 |
申请人 |
Orthopeutics L.P. |
发明人 |
Hedman Thomas P. |
分类号 |
A61K31/353;A61K31/70;A61K31/352;A61K31/7048 |
主分类号 |
A61K31/353 |
代理机构 |
Berliner & Associates |
代理人 |
Berliner & Associates |
主权项 |
1. A method of improving the resistance of a collagenous tissue having naturally occurring cross links to mechanically-induced degradation comprising the steps of:
contacting at least a portion of a load bearing collagenous tissue within a human body with an effective amount of a crosslinking reagent comprised of a carrier medium and at least one crosslinking agent under conditions within physiologic limits to prevent tissue overheating, wherein the collagenous tissue is an intervertebral disc. |
地址 |
Lexington KY US |