| 发明名称 | Polypeptides from non-typeable <i>Haemophilus influenzae</i> | ||
| 摘要 | Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by H. influenzae, such as otitis media. | ||
| 申请公布号 | US9102729(B2) | 申请公布日期 | 2015.08.11 |
| 申请号 | US201414264972 | 申请日期 | 2014.04.29 |
| 申请人 | Novartis Vaccines and Diagnostics SRL | 发明人 | Masignani Vega;Arico Beatrice Maria |
| 分类号 | A61K39/102;C07K14/285;A61K39/00 | 主分类号 | A61K39/102 |
| 代理机构 | Robins Law Group | 代理人 | Robins Law Group ;Robins Roberta L. |
| 主权项 | 1. An immunogenic composition comprising an effective amount of (a) an isolated, immunogenic polypeptide, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 1842 from Haemophilus influenzae strain 86-028NP, or the amino acid sequence of SEQ ID NO: 1842 that lacks a signal sequence; (b) a pharmaceutically acceptable carrier, and (c) an adjuvant. | ||
| 地址 | Emeryville CA US | ||