Antibody specific for apolipoprotein and methods of use thereof

摘要

The present disclosure provides synthetic antibodies specific for an epitope present on an apolipoprotein E polypeptide. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.

主权项

1. A humanized antibody that specifically binds an epitope in apolipoprotein E (apoE), wherein the epitope comprises amino acid residues within amino acids 222-230 (SEQ ID NO:14) and 261-272 (SEQ ID NO:19) of apoE, wherein the humanized antibody comprises a heavy chain region and a light chain region, wherein the heavy chain region comprises a heavy chain variable region comprising complementarity determining regions (CDRs) having amino acid sequences set forth in SEQ ID NO:2, SEQ ID NO:3, and SEQ ID NO:4, and the light chain region comprises a light chain variable region comprising CDRs having amino acid sequences set forth in SEQ ID NO:6, SEQ ID NO:7, and SEQ ID NO:8.