Color change surgical prep solution

摘要

This invention discloses a surgical prep solution formulation, either film forming or non-film forming, that changes color upon a change in pH to indicate that the solvent has sufficiently evaporated. The major components of this surgical prep solution include: antimicrobial agents, solvents, pH adjusters, color changing pH indicators, and optionally: film forming polymers, dyes and viscosity regulators. The pH of the solution may rise or fall depending on the pH of the original solution as compared with the normal pH range of the acid mantle of the human skin or the normal pH range of a sterilizing solution. As the pH changes, the pH indicator may cause the surgical prep solution to change color. Concurrently, as the fluids evaporate, the pH indicators interact with atmospheric CO2, causing the solution to change color based on the pH of the solution. The solution may also be used as coating for medical devices.

主权项

1. A method of disinfecting comprising:
providing a composition comprising an an antomicrobial agent and either: (a) one or more pH adjusters or (b) a color-changing pH indicator; when the composition comprises the color-changing pH indicator, adding the one or more pH adjusters to the composition in situ prior to application of the composition to a patient's skin; when the composition comprises the one or more pH adjusters, adding the color-changing pH indicator to the composition in situ prior to application of the composition to the patient's skin; applying the composition to the patient's skin; evaporating the composition; and visually inspecting the residue of the composition on the patient's skin for a change in color, wherein the one or more pH adjusters is an acid, a base, a pH buffer or a combination thereof, and wherein the composition undergoes a visible color change between a pH of about 4.0 to about 5.5.