Antibodies against glucagon receptor and their use

摘要

Disclosed are immunological compositions and methods for reducing activity of glucagon signaling using antibodies against glucagon receptor.

主权项

1. An isolated antibody or an antigen-binding portion thereof for specifically binding to a human glucagon receptor, comprising:
a heavy chain, or a light chain, or both the heavy chain and the light chain, wherein said heavy chain or antigen-binding portion thereof comprises a heavy chain variable region having the amino acid sequence as set forth in SEQ ID No. 12; and said light chain or antigen-binding portion thereof comprises a light chain variable region having the amino acid sequence as set forth in SEQ ID No. 28.