Methods of treating inflammation with compositions comprising lecithin oils and NSAIDS for protecting the gastrointestinal tract and providing enhanced therapeutic activity

摘要

A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulsion for internal, oral, direct or topical administration.

主权项

1. A method of reducing a GI toxic effect of a non-steroidal anti-inflammatory drug (NSAID) in a subject who ingests the NSAID, comprising administering the NSAID to the subject as an NSAID-in-oil suspension that comprises lecithin oil and an NSAID,
wherein the lecithin oil consists of soy lecithin components in sunflower oil and has about 33 to about 40 wt. % of phosphatidylcholine (PC), about 26 to about 31 wt. % triglycerides, about 8 to about 13 wt. % free fatty acids, and about 5 to about 9 wt. % glycolipids, and wherein the NSAID is in an association complex with a phospholipid of the lecithin oil.