Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy

摘要

The present invention provides a compound of formula I;;
or a pharmaceutically acceptable salt thereof, wherein X is defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.

主权项

1. A compound of the formula (I):wherein:
X is OH, O—C1-7alkyl or O—C6-10aryl; or a pharmaceutically acceptable salt thereof.