| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: claimed is stable in storage water-free composition for local treatment of psoriasis by application on skin, including homogeneous mixture of therapeutically effective quantity of calcipotriol in dissolved form; dissolving mixture, consisting of solvent based on fatty acid triglycerides, auxiliary solvent, selected from polyoxypropylene-15-stearyl ether, polyoxypropylene-11-stearyl ether, polyoxypropylene-14-butyl ether, polyoxypropylene-10-cetyl ether, polyoxypropylene-3-myristyl ether, polyoxypropylene-5-ceteth 20; and lipophilic penetration enhancer, selected from N-alkylpiperidone, N-alkylpyrrolidone, such as N-methylpyrrolodone, N-hydroxyalkylpyrrolidone or 2-pyrrolidone; where ratio of solvent, auxiliary solvent and penetration enhancer is in range from 50:25:25 to 75:10:15; and where said dissolving mixture is included into composition in amount, sufficient for effective calcipotriol dissolution, and water-free pharmaceutically acceptable carrier, including at least one paraffin.EFFECT: technical result consists in chemical stability of calcipotriol with absence of skin irritation.21 cl, 2 dwg, 5 tbl, 7 ex |
