ION CONCENTRATION DEPENDENT BINDING MOLECULE LIBRARY

摘要

Disclosed is a library primarily comprising a plurality of antigen binding molecules having different sequences and having at least one amino acid residual contained in the antigen binding domain said amino acid residual varying the binding activity of the antigen binding molecules with respect to the antigens according to the ion concentration conditions. Also disclosed are: a composition containing a plurality of polynucleotide molecules that code antigen binding molecules; a composition containing a plurality of vectors that contain the aforementioned polynucleotide molecules; a method for selecting the aforementioned antigen binding molecule; a method for isolating the aforementioned polynucleotide molecules; a method for preparing the aforementioned antigen binding molecules; and a pharmaceutical composition containing the aforementioned antigen binding molecules.