| 摘要 |
<p>ABSTRACT Alzheimer’s disease (AD) is a neurodegenerative disease which shows both age and gender dependence. Female reproductive hormone estrogen has been reported as one of the reason for longevity in females and protection against AD during reproductive phase however females are more prone to AD compared to males during post-reproductive phase. The present invention employs usage of males and hermaphrodite of Caenorhabditis elegans AD disease model, CL4176 strain, which expresses the human Amyloid-beta (Aß1–42) in C. elegans muscle tissues to study gender based difference in etiology of AD in humans. Gender based difference in etiology of AD requires separate model systems to check the mechanism of the disease occurrence and efficacy of potent drugs. Hence Caenorhabditis elegans model is also used to determine the role of gender in the etiology of Alzheimer's disease. Following invention is described in detail with the help of Figure 1 of sheet 1 which shows better tolerance to Aß toxicity, oxidative stress and better efficacy for Donepezil drug in CL4176 males compared to hermaphrodite. Figure 2 of sheet 2 which shows CL4176 males show up-regulated levels of DAF-16 mRNA compared to CL4176 hermaphrodites whereas HSF-1 mRNA levels are unaltered.</p> |
