发明名称 |
POLYVINYLPYRROLIDONE FOR THE STABILIZATION OF A SOLID DISPERSION OF THE NON-CRYSTALLINE FORM OF ROTIGOTINE |
摘要 |
The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof. |
申请公布号 |
HK1200335(A1) |
申请公布日期 |
2015.08.07 |
申请号 |
HK20150100819 |
申请日期 |
2015.01.23 |
申请人 |
UCB PHARMA GMBH;LTS LOHMANN THERAPIE-SYSTEME AG |
发明人 |
WOLFF, HANS-MICHAEL H-M;ARTH, CHRISTOPH C;QUERE, LUC L;MUELLER, WALTER W |
分类号 |
A61K;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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