Antibodies to Non-Functional Oligomeric P2X7 Receptors

摘要

The invention relates to purinergic receptors, to antibodies and related fragments thereof for binding to said receptors, to production of said antibodies and fragments and to sue of said antibodies and fragments for cancer detection and therapy. In particular the antibodies described bind specifically to non-functional P2X& receptors expressed by live cells.

主权项

1. An antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1:
FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4wherein:
FR1, FR2, FR3 and FR4 are each framework regions; CDR1, CDR2 and CDR3 are each complementarity determining regions;wherein:
CDR3 has an amino acid sequence of: (charged/polar/aromatic) charged/aromatic)XXXY(aromatic/aliphatic)(charged/neutral)(neutral/aliphatic)and where X represents any amino acid.