ASSISTED PARTICLE SIZE REDUCTION PROCESS

摘要

A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (iv)stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder.