摘要 |
PROBLEM TO BE SOLVED: To provide methods for producing isomers of muconic acid and muconate salts.SOLUTION: The invention provides a method for producing cis,trans- and trans,trans-isomers of muconate, which method comprises the steps of: providing cis,cis-muconate formed from a renewable carbon source by biocatalytic conversion; isomerizing the cis,cis-muconate to cis,trans-muconate under reaction conditions in which substantially all of cis,cis-muconate is isomerized to cis,trans-muconate; isolating the cis,trans-muconate; and crystallizing the cis,trans-muconate. The cis,trans-isomer can be further isomerized to the trans,trans-isomer. |