发明名称 |
Polypeptide and Lipophilic Moiety Conjugate Compositions, Formulations, and Uses Related Thereto |
摘要 |
In certain embodiments, this disclosure relates to pharmaceutical formulations for polypeptide and lipophilic moiety conjugates suitable for injection into humans and other animals and methods of preparation. In certain embodiments, the disclosure relates to a method of preparing the formulation comprising lyophilizing, solubilizing in ammonium acetate, filtering to create mono-disperse particles, re-lyophilizing, and solubilizing the micelles in a dextrose solution for injection. |
申请公布号 |
US2015216990(A1) |
申请公布日期 |
2015.08.06 |
申请号 |
US201314403187 |
申请日期 |
2013.05.17 |
申请人 |
TUFTS MEDICAL CENTER, INC. |
发明人 |
Kuliopulos Athan |
分类号 |
A61K47/48;A61K45/06;A61K47/26;A61K38/08 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
1. Micelles comprising polypeptide and lipophilic moiety conjugate salts in substantially pure form. |
地址 |
Boston MA US |