METHOD FOR COATING A MEDICAL DEVICE WITH A CONFORMAL HYDROGEL

摘要

Certain embodiments according to the present invention provide a method for forming medical devices conformally coated with a hydrogel having a wide variety of therapeutic uses. In one aspect, certain embodiments of the invention provide a method for forming a hydrogel-coated medical device comprising immersing a medical device in a polymer solution to form an adhesive layer on an outer surface of the medical device and contacting the medical device with a hydrogel precursor solution having a pH of less than 7 to react the adhesive layer with the hydrogel precursor solution and form a conformal hydrogel coating.

主权项

1. A method for forming a hydrogel-coated medical device, comprising:
(a) immersing a medical device in a polymer solution to form an adhesive layer on an outer surface of the medical device, wherein the adhesive layer comprises at least one polymer having:
i. at least one amine group;ii. pH-modifying abilities; andiii. reactivity with an activated ester; and (b) contacting the medical device with a hydrogel precursor solution having a pH of less than 7 to react the adhesive layer with the hydrogel precursor solution and form a conformal hydrogel coating.