| 主权项 |
1. A bioremodelable encasement structure, comprising:
a bioremodelable encasement structure formed from at least one sheet member comprising a bioremodelable composition, said bioremodelable composition comprising ECM from a mammalian tissue source selected from the group consisting of small intestine submucosa (SIS), urinary bladder submucosa (UBS), urinary basement membrane (UBM), liver basement membrane (LBM), stomach submucosa (SS), collagen, subcutaneous extracellular matrix, large intestine extracellular matrix, placental extracellular matrix, ornomentum extracellular matrix, heart extracellular matrix, and lung extracellular matrix, said ECM further comprising an antibiotic selected from the group consisting of actinomyocin, bleomycin, plicamycin, mytomycin and anthracyclines, said encasement structure having an internal region configured to receive a device therein, said encasement structure being configured to induce modulated healing of tissue when implanted in a subject, said modulated healing including modulation of inflammation of said tissue and induced cell and tissue proliferation, bioremodeling, and regeneration of tissue structures with site-specific structural and functional properties. |
