LIPID-ENCAPSULATED INTERFERING RNA

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for silencing gene expression by delivering nucleic acid-lipid particles comprising a siRNA molecule to a cell.SOLUTION: The present invention provides: stable nucleic acid-lipid particles (SNALP) useful for encapsulating one or more siRNA molecules, wherein a conjugated lipid is used for inhibiting the aggregation of siRNA, cationic lipids, non-cationic lipids, and particles; methods of making SNALPs comprising the siRNA; SNALPs comprising the siRNA; and methods of delivering and/or administering the SNALPs to a subject to silence expression of a target gene sequence.