发明名称 |
METHODS AND COMBINATIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS |
摘要 |
<p>Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflammatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.</p> |
申请公布号 |
WO2015116735(A1) |
申请公布日期 |
2015.08.06 |
申请号 |
WO2015US13376 |
申请日期 |
2015.01.28 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
KIRKLAND, JAMES, L.;TCHKONIA, TAMAR;ZHU, YI |
分类号 |
A61K45/06 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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