| 摘要 |
The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R2, R3, R4, R5 and R6 are as defined in the specification. Further objects of the invention are processes and intermediates for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.; |
| 主权项 |
1. A compound of the formula (I): wherein G is CH or nitrogen atom; W is an oxygen atom, NR1 or S(O)n; n is 0, 1 or 2; R1 and R3 independently represent hydrogen atom or an optionally substituted group selected from alkyl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heterocyclyloxy-alkyl and alkoxycarbonyl group; R2 is hydrogen or halogen atom, or an optionally substituted group selected from aryl, cycloalkyl and heterocyclyl group; R4 is hydrogen or halogen atom, or an optionally substituted alkyl or alkenyl group; R5 is hydrogen or halogen atom; R6 is hydrogen atom or NHR7; R7 is hydrogen atom, an optionally substituted group selected from alkyl, aryl, cycloalkyl and heterocyclyl group or —CO—R1 wherein R1 is as defined above; or a pharmaceutically acceptable salt thereof, with the proviso that the following compounds are excluded: 2,5-di(pyridin-4-yl)-thiophene-3-carboxylic acid amide, 2,5-di(pyridin-4-yl)-thiophene-3-carboxylic acid methylamide, 2,5-di(pyridin-4-yl)-4-methyl-pyrrole-3-carboxylic acid amide, 5-pyridin-4-yl-furan-3-carboxylic acid[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide, 5-pyridin-4-yl-furan-3-carboxylic acid (1-methyl-1,2,3,4-tetrahydro-quinolin-7-yl)-amide and N-[2-amino-1-(2,4-chlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-3-carboxamide. |
