发明名称 |
ICMT INHIBITORS |
摘要 |
The invention provides a 1,3,5-substituted indole wherein the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is CH2NR1R2 wherein R1 is H or C1 to C3 alkyl, R1 being optionally substituted with —OH, —SH, —NH2 or NHalkyl, wherein alkyl is a C1 to C4 alkyl group, and R2 is C1 to C3 alkyl or (CH2)n bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group. |
申请公布号 |
US2015218095(A1) |
申请公布日期 |
2015.08.06 |
申请号 |
US201314404912 |
申请日期 |
2013.05.30 |
申请人 |
National University of Singapore |
发明人 |
Ramanujulu Pondy Murugappan;Yang Tianming;Casey Mei-Wang;Casey Patrick J.;Go Mei Lin |
分类号 |
C07D209/14;C07D403/04;C07D471/04;C07D401/04 |
主分类号 |
C07D209/14 |
代理机构 |
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代理人 |
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主权项 |
1. A 1,3,5-substituted indole wherein:
the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is CH2NR1R2 wherein R1 is H or C1 to C3 alkyl, R1 being optionally substituted with —OH, —SH, —NH2 or NHalkyl, wherein alkyl is a C1 to C4 alkyl group, and R2 is C1 to C3 alkyl or (CH2)n bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group. |
地址 |
Singapore SG |