发明名称 |
Pharmaceutical compositions for oral treatment of diabetes |
摘要 |
<p>The present invention relates to pharmaceutical compositions for oral delivery comprising at least two bioactive proteins associated with glucose metabolism, selected from the group consisting of insulin, proinsulin and C-Peptide in a delivery vehicle adapted for oral administration that provides portal delivery of bioactive proteins. The exemplary pharmaceutical compositions comprise an oil-based matrix comprising solid particulate matter suspended therein, wherein the particulate matter comprises a polysaccharide non-covalently associated with silica particles having a hydrophobic surface, wherein the polysaccharide and silica particles are non-covalently associated with the at least two bioactive proteins. The present invention further provides therapeutic uses of said pharmaceutical compositions.</p> |
申请公布号 |
AU2014210751(A1) |
申请公布日期 |
2015.08.06 |
申请号 |
AU20140210751 |
申请日期 |
2014.01.29 |
申请人 |
OSHADI DRUG ADMINISTRATION LTD. |
发明人 |
VOL, ALEXANDER;GRIBOVA, ORNA |
分类号 |
A61K38/28;A61P3/08;A61P3/10 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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