发明名称 |
Methods and Systems for Rapid Detection of Microorganisms using Infectious Agents |
摘要 |
Disclosed herein are methods and systems for rapid detection of microorganisms in a sample, without culturing for enrichment of the microorganism. A modified bacteriophage is also disclosed which comprises a non-native indicator gene in the late gene region. The indicator product is not a fusion protein. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity. |
申请公布号 |
US2015218616(A1) |
申请公布日期 |
2015.08.06 |
申请号 |
US201514625481 |
申请日期 |
2015.02.18 |
申请人 |
Laboratory Corporation of America Holdings |
发明人 |
Anderson Dwight Lyman;Gil Jose S.;Hopkins Ben Barrett;Erickson Stephen |
分类号 |
C12Q1/66 |
主分类号 |
C12Q1/66 |
代理机构 |
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代理人 |
|
主权项 |
1. A recombinant bacteriophage comprising an indicator gene inserted into a late gene region of the bacteriophage. |
地址 |
Burlington NC US |