| 摘要 |
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene and OX40 signaling pathway. The proteins of the invention are useful in modulating both regulatory T cells and effector T cells. Compelling evidence from model systems points to immune surveillance mechanisms that can recognize and eliminate tumor cells. Yet established cancers commonly resist immune eradication, attributable in part to immunosuppressive elements within tumor microenvironments that limit the anti-tumor activity of infiltrating CD8+ cytotoxic T lymphocytes and other immune effectors. A variety of immunosuppressive mechanisms have been suggested to date, including tumor-intrinsic events, soluble suppressive factors, and regulatory cells capable of actively inhibiting effector T cell responses. |
