发明名称 NOVEL ANTI-BAFF ANTIBODIES
摘要 The present invention relates to anti-BAFF antibody molecules, including novel humanized anti-BAFF antibodies, therapeutic and diagnostic methods and compositions for using the same.
申请公布号 US2015218267(A1) 申请公布日期 2015.08.06
申请号 US201514609756 申请日期 2015.01.30
申请人 Boehringer Ingelheim International GmbH 发明人 BRODEUR Scott Ronald;CANADA Keith;DZIEGELEWSKI MIchael;GORMAN Philip Nicholas;GUPTA Pankaj;KHALIL Ashraf;MIGLIETTA John James;NICOLETTI Amy Marie;PAN Qi;PRESKY David;SINGH Sanjaya;WU Tao;Xiao Haiguang
分类号 C07K16/24 主分类号 C07K16/24
代理机构 代理人
主权项 1. An anti-BAFF antibody molecule comprising a light chain variable domain with a CDR1 selected from the group consisting of any one of SEQ ID NO: 1, 5, 10, 13, 15, 76, 77, 78, 79, 80, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274 and 275, a CDR2 selected from the group consisting of any one of SEQ ID NO: 2, 6, 8, 11, 16, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291 and 292, and a CDR3 selected from the group consisting of any one of SEQ ID NO: 3, 4, 7, 9, 12, 14, 17, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310 and 311; and a heavy chain variable domain with a CDR1 selected from the group consisting of any one of SEQ ID NO: 18, 21, 23, 25, 28, 31, 34, 36, 37, 81, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 392, 333, 334, 335 and 336, a CDR2 selected from the group consisting of any one of SEQ ID NO: 19, 24, 26, 29, 32, 35, 38, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366 and 367, and a CDR3 selected from the group consisting of any one of SEQ ID NO: 20, 22, 27, 30, 33, 39, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390 and 391.
地址 Ingelheim am Rhein DE