P15 PROTEIN VARIANT AND USE THEREOF FOR PREVENTING OR TREATING CANCER

摘要

A p15 protein variant; a polynucleotide encoding the p15 protein variant; a method for preparing the p15 protein variant; a pharmaceutical composition comprising the p15 protein variant; and a method for preventing and/or treating cancer comprising administering the p15 protein variant to a subject.

主权项

1. A recombinant or synthetic p15 protein variant comprising a p15 protein in which at least one hydrophobic amino acid residue that is externally exposed on the tertiary structure of the p15 protein in aqueous solution is substituted with a hydrophilic amino acid, wherein the hydrophobic amino acid is leucine (L), cysteine (C), valine (V), phenyl alanine (F), tryptophan (W), isoleucine (I), proline (P), methionine (M), or a combination thereof; and the hydrophilic amino acid is lysine (K), aspartic acid (D), glutamic acid (E), glutamine (Q), asparagine (N), serine (S), alanine (A), threonine (T), arginine (R), or a combination thereof.