| 发明名称 |
6-AMINOINDOLE DERIVATIVES AS TRP CHANNEL ANTAGONISTS |
| 摘要 |
The invention is concerned with the compounds of formula (I);;and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) can be used as medicament. |
| 申请公布号 |
US2015218133(A1) |
申请公布日期 |
2015.08.06 |
| 申请号 |
US201514689828 |
申请日期 |
2015.04.17 |
| 申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
Chen Zhi;Erickson Shawn David |
| 分类号 |
C07D401/14;C07D209/12;C07D401/04 |
主分类号 |
C07D401/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of formula (I) wherein: X is —CH— or nitrogen; R1 is lower alkoxy; R2 is halogen; R3 is hydrogen or lower alkoxy; one of R4 or R4′ is hydrogen or lower alkyl and the other is hydrogen or —C(O)—R5; and R5 is alkoxy, —CF3, —CHF2, lower alkyl, chlorophenyl or (fluoro-benzenesulfonyl)-piperidinyl; or a pharmaceutically acceptable salt thereof |
| 地址 |
Little Falls NJ US |
