COMPOSITIONS FOR THE DELIVERY OF RNA AND DRUGS INTO CELLS

摘要

Provided is a co-polymer of formula A-L-D, or a pharmaceutically acceptable salt thereof, wherein A is a linear, branched or dendritic polyamine; D is a lipid; and L is a linker comprising a water soluble polymer; wherein L is connected to A at a first end through a first covalent bond and connected to D at a second end through a second covalent bond.

主权项

1. A co-polymer of formula (I)
A-B-C-D   (I)or a pharmaceutically acceptable salt thereof, wherein
A is a poly(amidoamine) dendrimer (PAMAM); B is selected from the group consisting of a bond, —CO—, —COO—, —CONR5—, —CH2CH2CO—, —CH2CH2COO—, —CH2CH2CONR5—, —SO2— and —SO2NR5—; C is —(R4O)n—; D is F, EF or E(F)2; E is selected from the group consisting of a bond, —COO—, —CONR5—, —CH2CH2COO—, —CH2CH2CONR5—, —SO2NR5—; F is —CO—C6-C22-alkyl or —CO—C6-C22-alkenyl; R3 is C2-C8 alkylene, optionally substituted; R4 is C2-C8 alkylene, optionally substituted; R5 is hydrogen or C1-C6 alkyl, optionally substituted; n is from 1 to 50; and m is from 1 to 50.