TUMOR SELECTIVE ANTIBODIES SPECIFIC TO ONCOFETAL ANTIGEN/IMMATURE LAMININ RECEPTOR PROTEIN

摘要

Disclosed are high affinity antibodies or antigen-binding fragments thereof, which bind an epitope that lies within the C-terminal region of oncofetal antigen (OFA)/immature laminin receptor protein (iLRP), and which do not substantially cross-react with mature OFA/LRP. The antibodies may be conjugated to cytotoxic moieties to enhance their therapeutic efficacy. Methods of making the antibodies and therapeutic and diagnostic uses thereof are also disclosed.

主权项

1. An antibody or a single-chain or antigen-binding fragment thereof that specifically binds a C-terminal epitope of oncofetal antigen (OFA)/immature laminin protein (iLRP) present on a tumor/cancer cell and which does not substantially cross-react with mature OFA/LRP or with non-cancer cells, wherein the antibody specifically binds an epitope in the C-terminal region of oncofetal antigen (OFA)/immature laminin protein (iLRP) with a binding affinity (KD) of at least 5.0×10−1° M (±5.0×10−12 M), as measured by surface plasmon resonance.