| 摘要 |
PROBLEM TO BE SOLVED: To provide fusion proteins forming trimers which allow efficient recombinant manufacture combined with good trimerization properties and improved pharmaceutical properties. ! SOLUTION: The present invention relates to a fusion protein comprising (i) a collectin family trimerization domain comprising a. a collectin family Carbohydrate Recognition Domain; and b. a collectin family neck region; (ii) a linker element; and(iii) an effector polypeptide, wherein the effector polypeptide is located N-terminally in the collectin family neck region. The fusion proteins, and the nucleic acid encoding the same are suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications as described herein. ! COPYRIGHT: (C)2015,JPO&INPIT |
