DOSING REGIMENS FOR SUBCUTANEOUSLY INFUSIBLE ACIDIC COMPOSITIONS

摘要

The invention features methods, compositions, dosing regimens, and infusion pumps for subcutaneously infusing acidic solutions of L-DOPA prodrugs, such as esters and amides of L-DOPA, for the treatment of Parkinson's disease. The methods and acidic compositions of the invention can reduce the severity and rate of occurrence of transient local swelling, erythema, and persistent subcutaneous granulomas associated with subcutaneous delivery of certain agents used in the treatment of Parkinson's disease.

主权项

1. A pharmaceutical composition comprising an aqueous solution containing from 0.15 to 1.6 M LD prodrug acid addition salt and having a pH of from 2.1 to 3.9, wherein said pharmaceutical composition is subcutaneously infusible.