| 发明名称 |
COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA |
| 摘要 |
Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites. |
| 申请公布号 |
US2015216954(A1) |
申请公布日期 |
2015.08.06 |
| 申请号 |
US201514623050 |
申请日期 |
2015.02.16 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ;THE TEXAS A&M UNIVERSITY SYSTEM ;THE UNIVERSITY OF GUELPH |
发明人 |
Bottje Walter;Hargis Billy;Berghman Luc;Kwon Young Min;Cole Kimberly;Cox Mandy;Layton Sherryll;El-Ashram Said;Barta John;Tellez Guillermo |
| 分类号 |
A61K39/002 |
主分类号 |
A61K39/002 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A vaccine comprising a vector comprising a first polynucleotide sequence encoding a thrombospondin-related anonymous protein (TRAP) polypeptide of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3 or an immunogenic fragment thereof comprising at least six consecutive amino acids of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. |
| 地址 |
LITTLE ROCK AR US |
