Use Of Flap Inhibitors To Reduce Neuroinflammation Mediated Injury In The Central Nervous System

摘要

The present invention provides methods of attenuating or preventing brain injury mediated damage in the central nervous system by attenuating or preventing leukotriene-mediated events following a brain injury or long-term neuroinflammation after brain injury, in Alzheimer's disease, multiple sclerosis, stroke, and post-traumatic stress disorder. The methods comprise administering at least one 5-lipoxygenase activating protein (FLAP) inhibitor either before or after the brain injury. The method finds use in the treatment of traumatic brain injury (TBI), stroke, multiple sclerosis, Alzheimer's disease, post-traumatic stress disorder and other brain injuries associated with production of leukotrienes in the central nervous system. Preferably the FLAP inhibitor is administered intranasally and preferably for certain high risk individuals prophylactically prior to any potential brain injury event.

主权项

1. A method of treating neuroinflammation caused by a brain injury event in an animal comprising the steps of:
providing a 5-lipoxygenase activating protein (FLAP) inhibitor, wherein said FLAP inhibitor is able to cross the blood brain barrier of an animal; administering said FLAP inhibitor to said animal in an amount and at a time either before a brain injury event or a time after a brain injury event wherein said amount and said time is sufficient for said FLAP inhibitor to reduce a level of leukotrienes produced in a brain of said animal as a result of said brain injury event.