发明名称 |
AN HIV-1 GP120 MINI V3 LOOP AND USES THEREOF |
摘要 |
<p>The invention relates to an immunogenic HIV-1 gp120 mini V3 loop, which is a truncated version of the full-length gp120 V3 loop useful for crystallization with antibodies that recognize carbohydrate moieties. The invention also relates to the structure of a broadly neutralizing antibody as a complex with a glycosylated gp120 outer domain, as determined by crystallographic techniques, and the confirmation that a glycosylated gp120 outer domain has a functional relevant conformation, as well as the determination of key residues on a glycosylated gp120 outer domain, and uses thereof and compounds and compositions therefrom. Furthermore, the invention also relates to other peptides and mimetic peptides, which bind to broadly neutralizing antibodies.</p> |
申请公布号 |
EP2766037(A4) |
申请公布日期 |
2015.08.05 |
申请号 |
EP20120840238 |
申请日期 |
2012.10.11 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
WILSON, IAN, A.;STANFIELD, ROBYN, L.;PEJCHAL, ROBERT |
分类号 |
A61K39/00;A61K39/12;A61K39/21;A61K39/395;A61K39/42;C07K16/10;C07K16/44;G01N33/569 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|