发明名称 |
IMPROVED METHODS FOR THE ACYLATION OF MAYTANSINOL |
摘要 |
Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an N-carboxyanhydride of an amino acid. |
申请公布号 |
EP2900676(A1) |
申请公布日期 |
2015.08.05 |
申请号 |
EP20130774881 |
申请日期 |
2013.09.26 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
WIDDISON, WAYNE C.;ZHAO, ROBERT YONGXIN |
分类号 |
C07D498/18 |
主分类号 |
C07D498/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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